Doctor Octopus - Spider-Man 2 (2004)
Dr Otto Octavius (aka Doc Ock) suffers horribly, like so many Marvel characters, from alliterative name syndrome ( J Jonah Jameson, Peter Parker, Curt Connors), but is sent over the edge when an experiment goes awry, killing his missus and leaving him with four metal arms seared to his body.
Eventually kills himself. Pass the popcorn!
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