5. Operation

The Talent: Matt Damon, Vera Farmiga, director Steven Soderbergh

The Pitch: Soderbergh decides to take a psychedelic, brain-troubling approach to the story of a man (Damon) who is critically afraid of going in to have his tonsils out.

We follow him under anesthetic as he has a trippy, crazed adventure through his own body, constantly fearing for his organs at the hands of a mad surgeon.

The only thing that can save him is the love of his wife (Farmiga). And his nose, which burns bright red when he's in danger.

The Cost: $30 million. Soderbergh promises to bring it in on budget, and just about succeeds.

The Box Office: $100 million worldwide.

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