Sherilyn Fenn
Last trip to Lynch-land: As volatile sex-fox Audrey Horne in Twin Peaks TV series (1990-1991) and the sticky-brained crash-girl in Wild At Heart (1990). Or, for a more lateral Lynch connection, Boxing Helena (1993) was directed by daughter Jennifer...
Since then: Dated Prince, called off engagement to Johnny Depp, various TV movies and guest spots on the likes of House, Outer Limits, CSI), played Elizabeth Taylor in an NBC special... Someone, please, give this woman a second career act.

Madchen Amick
Last trip to Lynch-land: As waitress Shelly Johnson in Twin Peaks TV series (1990-1991) and feature-length version Twin Peaks: Fire Walk With Me (1992).
Since then: Shonky TV movies, straight-to-DVD sci-fis and cancelled sitcoms. Enjoyed a reasonable stint in Dawson's Creek as the substitute teacher. Recent (slight) re-emergence as a regular in the second series of Californication.