The TV Show: Clooney made his screen debut as an extra in series Centennial in 1978, though his first major role came along with E/R – not to be confused with E.R. A 1984 sitcom that only lasted one season, E/R was set in a hospital and starred Elliot Gould.
Of course, Clooney would return to the emergency room a decade later for E.R., in which he reached fever pitch heartthrob fame as Dr Ross.
The Breakout Movie: Clooney’s first major film role was From Dusk Till Dawn, which saw him team up with Quentin Tarantino and wasting vampires.
Any Similarities: Though he certainly is in desperate need of ER, Dawn couldn’t be further away from that clinical TV drama.