Another classic villain to consider. So classic, in fact, that he's listed as the first major villain that Parker battles in the comics.

Russian-born Dmitri Smerdyakov (Stan Lee really reaching for a Ruskie name there) got his start as a servant to Kraven The Hunter, but was fighting with the web-warrior before his old master. With his ability to mimic any human face, he's a great choice for a role that could be played by several actors.

The Bruce Factor: He might not want to hide his famous chin behind a CG mask, nor share the part with others, but Bruce let loose with makeup and madness? Bring, It. On.