Jeff Goldblum has a terrible bit of luck as the titular anti-hero scientist, whose experimentation with hybridisation goes horrifically awry when his DNA gets fused with that of, yes, a fly. The worst bit comes when he loses a particularly important appendage. Men everywhere cross their legs. Forever. Youch.
Originally set out as a project for Tim Burton, The Fly eventually landed with David Cronenberg instead – and what fortune that it did, the body horror guru plumbing devastating depths with his own ooky spin on Frankenstein’s monster.