Jonze' second collaboration with Kaufman, though this time he didn't direct, he just produced, handing over the reigns to fellow helmer Michel Gondry, with whom he created the Director's Label DVD series featuring the work of various advert and music video makers.

Human Nature stars Rhys Ifans as a man who was raised as an ape and ends up raising temperatures for the scientists - Tim Robbins and Patricia Arquette - trying to socialize him.

It never achieved the success levels of Malkovich, but Jonze explained why he was drawn to it: "That’s why Charlie’s scripts are fun to read. When I first read the script, it just kept going to different places, and that probably comes from Charlie not knowing where he’s going."