Sandra starred alongside Tate Donovan in this romantic comedy, and the pair ended up dating for a number of years in real-life.

The story is pretty simple: a pair of geeky scientists (Donovan and Bullock) get their hands on the titular love drug that makes the user irresistible to the opposite sex (it's tested on a couple of lusty chimps early on). Unsurprisingly, the pair end up falling for each other and have to find a way of purifying their love whilst being weaned off the drug.

Hollywood's Sweetheart? Not a huge hit, but it showed she wasn't afraid to ugly up and goof around.