In a nutshell:

A cursed prince and a Demon princess must join forces to reconcile technology and nature, and avert an apocalyptic battle.

Trailer:

Tagline:

The fate of the world rests on the courage of one warrior.
 
Quotes:

"Even if you were a woman you'd be stupid!"

"Disgusting little creatures! Soon all of you will feel my hate, and suffer
as I have suffered!"

"Hey! You're not handsome, you're gorgeous!"

Plot:

When an enraged boar-god-turned-giant-demon comes out of the woods and threatens a small community, Prince Ashitaka (Yōji Matsuda/Billy Crudup) is forced to kill the creature.

He is cursed when the demon slurry surrounding the creature touches his arm, enabling him to decapitate or de-limb samurai with a single arrow, and perform other super-human feats.

Unfortunately, the curse is slowly taking over his body. Soon it will kill him, so he goes in search of a cure.

On the way he encounters a mysterious monk called Jigo who tells him about the animal gods who live in the dangerous forest to the west.

A band of humans heading home to Iron Town are attacked by the giant Wolf god Moro (Akihiro Miwa/Gillian Anderson), her two children and her adopted human child San (Yuriko Ishida/Claire Danes), The Princess Mononoke.

San has been raised by Moro and is engaged in a ferocious war with mankind to defend the forest.

On the opposite side, the humans of Iron Town are led by the fearless and cunning Lady Eboshi (Yūko Tanaka/Minnie Driver).

There are atrocities committed by all sides and only Ashitaka seems willing to seek a peaceful coexistence between man and nature.

Written by: TheRealEverton